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Journal of Chemical Physics / Volume 133 / Issue 2 / ARTICLES / Polymers and Complex Systems

J. Chem. Phys. 133, 024902 (2010); http://dx.doi.org/10.1063/1.3458821 (11 pages)

Polymer translocation through pores with complex geometries

Aruna Mohan, Anatoly B. Kolomeisky, and Matteo Pasquali

Department of Chemistry and Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, USA

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(Received 2 May 2010; accepted 9 June 2010; published online 12 July 2010)

We propose a method for the theoretical investigation of polymer translocation through composite pore structures possessing arbitrarily specified geometries. The proposed method accounts for possible reverse chain motions at the interface between the constituent parts of a composite pore. As an illustration of our method, we study polymer translocation between two spherical compartments connected by a cylindrical pore and by a composite pore consisting of two connected cylinders of different diameters, which is structurally similar to the α-hemolysin membrane channel. We demonstrate that reverse chain motions between the pore constituents may contribute significantly to the total translocation time. Our results further establish that translocation through a two-cylinder composite pore is faster when the chain is introduced into the pore on the cis (wide) side of the channel rather than the trans (narrow) side.

© 2010 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. TWO SPHERES CONNECTED BY A CYLINDER
    1. Free energy landscape
    2. Translocation time
    3. Results
  3. TWO SPHERES CONNECTED BY A COMPOSITE TWO-CYLINDER PORE
  4. CONCLUSIONS

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KEYWORDS and PACS

Keywords

biomembranes, biotransport, composite materials, polymers, porous materials

PACS

  • 87.16.dp

    Transport, including channels, pores, and lateral diffusion

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3458821

PUBLICATION DATA

ISSN

0021-9606 (print)  
1089-7690 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

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