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Journal of Chemical Physics / Volume 135 / Issue 10 / ARTICLES / Biological Molecules, Biopolymers, and Biological Systems

J. Chem. Phys. 135, 105101 (2011); http://dx.doi.org/10.1063/1.3634006 (6 pages)

Polymerization of actin filaments coupled with adenosine triphosphate hydrolysis: Brownian dynamics and theoretical analysis

Kunkun Guo1,2,3, Wenjia Xiao1, and Dong Qiu2

1College of Materials Science and Engineering, Hunan University, Changsha 410082, China
2Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, 100190 Beijing, China
3Theory & Bio-systems, Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany

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(Received 30 June 2011; accepted 18 August 2011; published online 12 September 2011)

Polymerization dynamics of single actin filaments coupled with adenosine triphosphate (ATP) hydrolysis is investigated via both theoretical analysis and Brownian dynamics simulations. Brownian dynamics simulations have been applied recently to study the growth behaviors of long filaments as a function of the free actin monomer concentrations, CT, which is found to be in agreement with the associated experiments. In the present study, both ATP cap length and length diffusivity are studied as a function of the free ATP-actin monomer concentrations, CT. The exact analytical expressions are found to be in perfect consistency with Brownian dynamics simulations. Likewise, we find that the length diffusion coefficient is peaked near the critical concentration, CT, cr. It is, therefore, expected that the dependence of length diffusivity on ATP-actin monomer concentrations is utilized to analyze the surprising experiments on the length fluctuations of individual actin filaments.

© 2011 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. THEORETICAL APPROACH
    1. Brownian dynamics simulations
    2. Analytical expressions
  3. RESULTS AND DISCUSSIONS
  4. CONCLUSIONS

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KEYWORDS and PACS

Keywords

biochemistry, biodiffusion, Brownian motion, molecular biophysics, molecular configurations, polymerisation, proteins

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3634006

PUBLICATION DATA

ISSN

0021-9606 (print)  
1089-7690 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    X. Li, Y. Kierfeld, and R. Lipowsky, Phys. Rev. Lett. 103, 048102 (2009).

    K. Guo, J. Shillcock, and R. Lipowsky, J. Chem. Phys. 131, 015102 (2009)JCPSA6000131000001015102000001.

    K. Guo, J. Shillcock, and R. Lipowsky, J. Chem. Phys. 133, 155105 (2010)JCPSA6000133000015155105000001.


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